Development of a Minimally Invasive Surgical Device for the Treatment of Esophageal Cancer

DESCRIPTION provided by applicant The treatment of Esophageal Cancer has experienced a palpable increase in the last few years While numerous options are currently under investigation many if not all remain suboptimal This is critical as it is estimated that in there were new cases and over deaths from esophageal cancer worldwide In the US alone there were new cases and over deaths from esophageal cancer Adding to this of individuals suffering from gastroesophageal reflux disease GERD will develop Barrettandapos s esophagus which has been shown to be a precursor factor for the development of esophageal cancer This places another andgt individuals in the US alone suffering from this chronic disease at an increased risk for development of esophageal cancer annually While various treatment options currently exist a number of issues have been reported including the high cost of treatment patient discomfort complications incomplete treatment and poor efficacy among others With a yr survival rate for esophageal cancer patients of andlt yielding a reported deaths in alone there is an ever growing urgency and compelling need for the development of new strategies and devices to treat both esophageal cancer and Barrettandapos s esophagus The intent of this project is to develop and characterize an innovative flexible closed loop balloon catheter based endoscopic device FrostBite for the treatment of esophageal cancer and Barrettandapos s esophagus employing a minimally invasive outpatient procedure The prototype device and preliminary data collected to date strongly support the potential of this approach The major goals of this Phase proposal are to develop the FrostBite balloon catheter investigate the cell molecular response of cancerous and non cancerous esophageal cells to thermal ablation develop and test FrostBite in an ex vivo tissue model and conduct a pilot in vivo study for validation and technology procedural development The successful completion of this project will lead to a new technology and therapy for the management of esophageal cancer as well as provide data in support of establishing the thermal dose parameters necessary for optimal clinical application of the proposed device as well as other ablation technologies for the treatment of esophageal cancer and Barrettandapos s esophagus Once completed this project will provide for an effective minimally invasive treatment option for individuals suffering from esophageal cancer as well as Barrettandapos s esophagus contributing to efforts for improving patient survival quality of life and mitigating risk factors for cancer diagnosis PUBLIC HEALTH RELEVANCE This application proposes to develop a novel medical device for the treatment of esophageal cancer and Barrettandapos s Esophagus