Real-time 3D Imaging Guided ART

DESCRIPTION provided by applicant The United States have the highest annual incidence rates of breast cancer in the word It is the second most common cancer after skin cancer and the second most common cause of cancer death after lung cancer It is estimated that in there will be an estimated new cancer cases diagnosed and cancer deaths in the US Worldwide more than one million new cases of breast cancer are found every year Apparently an effective or accurate minimally invasive and low cost solution for breast cancer treatment will have enormous clinic impact and significance on saving womenandapos s lives To address the problems and technical challenges facing breast radiation therapy RT together with its collaborator we proposes a radically different methodology called D SGRT technology to dynamically compute on treatment breast anatomy structure and adaptively re plan the radiation therapy The proposed technology uses a non invasive and adaptive image guidance based methodology It eliminates uncertainties due to setup mobility and deformation for optimized delivery It is also expected to shortened breast RT session with improved accuracy and reduces minimum treatment setup time Successful completion of the project will provide foundation for the next generation breast RT and make it possible for millions of breast cancer patients to benefit from the most recent technological advances in a timely fashion The radiation therapy market is growing rapidly with annual cancer rates worldwide projected to increase by fifty percent by mainly due to aging population increasing number of smokers and unhealthy life styles The Fredonia Group estimated that U S has $ billion US market for cancer therapies and it is growing ten percent annually With over radiation treatment machines in the US and many more in the world the market for a clinically acceptable D camera enabled adaptive therapy system is significant PUBLIC HEALTH RELEVANCE The D SGRT technology developed under this SBIR project will have enormous clinical impact and significance on saving womenandapos s lives through an effective or accurate non invasive imaging guided and low cost solution The proposed radically different methodology eliminates the use of on board radiation for the pre treatment verification process Instead it relies on a non invasive modality to dynamically compute the on treatment breast anatomy structure virtual on treatment CT and then adaptively re plans the radiation therapy in real time It thus eliminates uncertainties due to setup mobility and deformation for optimized delivery Once completed the technology is also expected to shortened breast RT session with improved accuracy and reduces minimum treatment setup time