Drug containing hydrogels which release nitric oxide for diabetic wound healing

DESCRIPTION provided by applicant The goal of this Phase I proposal is to discover and develop compounds which can release a therapeutically relevant amount of nitric oxide in a controllable manner formulate them into a hydrogel wound dressing and demonstrate their ability to promote the healing of diabetic wounds in an in vivo model To date development of nitric oxide for these purposes has been hampered by the inability to stably sequester nitric oxide and release it in a controlled and selective way Traditional treatment with gaseous nitric oxide is impractical due to the cumbersome high pressure gas tanks needed The work undertaken in this project will i identify novel compounds which stably sequester nitric oxide and only release it when they come in contact with a wound ii formulate these into a suitable hydrogel for delivery to the wound and iii identify the proper kinetics of release needed to deliver the appropriate dose of nitric oxide to the wound in vivo We will prepare several small libraries of compounds analogs in total which release nitric oxide at varying rates when exposed to plasma These compounds will also be assayed for nitric oxide release formulated into hydrogels and tested in a mouse model of diabetic wound healing PUBLIC HEALTH RELEVANCE The goal of this Phase I proposal is to discover and develop novel compounds which release nitric oxide in a controlled fashion upon contact with wounds These compounds which will be formulated into a hydrogel are useful for the treatment of diabetic wounds and can greatly increase the rate of wound healing and lessen the amount of scarring