Developing the Dietary Inflammatory Index for Clinical Application

DESCRIPTION provided by applicant A large persuasive and ever increasing body of evidence links chronic inflammation to virtually all of the chronic diseases that cause the majority of disability and death in the U S including diabetes cardiovascular diseases CVD and cancer Diet plays a central role in the regulation of chronic inflammation However until we developed the dietary inflammatory index DII there had been no scientifically valid way to relate what individuals eat to the capacity of foods consumed to modulate inflammation The new generation DII has now produced an impressive research base that ranges from predicting blood levels of inflammatory markers to clinical conditions associated with inflammation to a variety of health related endpoints including cancer incidence and mortality Connecting Health Innovations CHI and our scientific and clinical research partners at the University of South Carolina are committed to translating these research findings to places of clinical need andPUBLIC HEALTH RELEVANCE Although we know both that chronic systemic inflammation is linked to virtually all of the chronic diseases that cause the majority of disability and death in he U S and that diet plays a central role in the regulation of chronic inflammation there is virtualy no data linking all three factors With our development of the dietary inflammatory index DII we have been able to fill this void The work proposed here will allow us to translate an impressive body of evidence based results linking diet inflammation and health related endpoints to places of clinical need and public health relevance