Physiologically Compatible Hemodialysis through Advanced Dialysate Regeneration

The uremic syndrome is a disabling condition attributed to the progressive retention of solutes that would normally be excreted by the kidneys and which interact negatively with physiological systems/functions. These are broadly defined as uremic toxins. Hemodialysis treatment is prescribed for the majority of individuals in the final stages of renal failure. However, better dialysis options (length, frequency and location) are needed to enable individuals with this disability to work and engage in activities in their communities. With the goal of creating an advanced, portable hemodialysis system based on an innovative dialysate regeneration system, the investigators will use various surface chemistry techniques to develop an adsorption system effective for regenerating spent dialysate containing a wide spectrum of uremic toxins AND maintain nutrients such as amino acids, vitamins and essential ions. The technical objectives in the Phase I program are: 1) Design, Preparation and Characterization of the Advanced DRS; 2) Performance Characterization of the Advanced DRS for Uremic Toxin Clearance; 3) Efficacy and Safety Test on DRC Housing the Advanced DRS; 4) Summary of Phase I Program. The challenge in this Phase I project will be identifying an adequate balance between the degree of selectivity and the toxin removal effectiveness.