Technologies That Reconstruct or Regenerate Vascular Tissue in the Extremities After Traumatic Injury

Techshot is pleased to provide this proposal utilizing our scaffold fabrication and regenerative medicine experience together with Dr. Boland?s longstanding research interest in developing a tissue engineered vascular graft. We are proposing an off the shelf bioactive vascular graft capable of remodeling in situ to provide a long term solution to revascularization due to traumatic injury. In this proposed research, an electrospinning system to produce clinically-appropriate sized peripheral vascular grafts is being developed as well as a novel graft conduit. The graft will be comprised of natural and synthetic polymers that are capable of in situ remodeling to leave a natural vessel upon complete healing. Stromal cells taken from the patient?s own fat will be used to induce this remodeling. We believe that the regenerative cell populations found in adipose represents a clinically feasible source of cells for vascular-dependent tissue repair. Success will be achieved through careful design and evaluation of electrospun scaffolds, cell isolation and characterization systems, cell delivery systems, and characterization of the fate and effect of delivered cells.