Effective New Topical Treatment to Reduce Scar Formation in Burns

Thermal injury is common in military conflicts due primarily to the widespread use of explosive devices. Though scar formation is a natural process of wound healing, burns can produce scars that are excessive, physically debilitating and functionally damaging. Synedgen has demonstrated the efficacy of a safe topical treatment to reduce inflammation, prevent infection in, improve the healing rate of and reduce the magnitude of scar formation in burns. Synedgen uses a derivative of a natural biopolymer to prevent the initial stages of inflammation due to damage and necrotic tissue. Consequently, the burn healing process shifts to a regenerative phase earlier and is stimulated to heal, without the complications of unmitigated inflammation. This product can be used alone or in combination with other products to provide better management of burn wounds. This Phase II proposal will accelerate the development of this product into the clinic by completing studies of preclinical efficacy in animal models, complete the molecular validation of the polymer active ingredient and provide detailed steps and timelines for bringing this product to clinical trials.