Intelligent Sensor for Closed-Loop Anesthesia Delivery System

In Phase II, Physical Optics Corporation (POC) proposes to advance the development of the Intelligent Sensor Closed Loop Anesthesia Delivery (iSCAD) system that was shown to be feasible in meeting the Army Medical Research and Material Command"s need for a closed-loop anesthesia delivery system. The key innovation in the iSCAD is its novel system design based on multisensory fusion that allows accurate detection of propofol in blood and a fusion of physiological parameters to maintain an adequate depth of anesthesia in a subject. In Phase I, POC conclusively demonstrated the feasibility of the iSCAD system by validating the system and sensor concept through system design, analysis, pharmacokinetic (PK) modeling and simulations, assembly and testing of a proof-of-concept prototype. The Phase I project has eliminated the initial risk and created a clear path for the engineering development of the technology in Phase II, which will focus on optimization, engineering risk reduction and testing. Phase II will culminate in a fully functional, technology readiness level (TRL) 5/6 iSCAD system that will be ready for full certifications, engineering and regulatory documentation, further clinical testing and pre productization, certification.