Non-invasive Continuous Hydration Monitoring

DESCRIPTION provided by applicant The appropriate treatment regimen for dehydration mandates the accurate assessment of fluid deficit and the gradual correction of that deficit To this end the skin turgor test a k a the andquot skin pinch testandquot is widely performed to assess the degree of fluid loss or dehydration This highly subjective test has been found in numerous studies to be an inaccurate measure of dehydration in all but the most severe cases and hence is not suitable for assessing overall hydration status Alternatively new techniques able to measure the galvanic skin response GSR have resulted in the demonstration of wearable devices able to quantify the relative hydration level of the wearer However it is widely realized that this too is a highly inaccurate measure of hydration as the measurement is easily confounded by the sympathetic nervous system response amount of adipose tissue temperature humidity and hydration of the stratum corneum itself which can be skewed by age as well as various topical creams and ointments This project aims to address the above limitations of conventional hydration monitoring techniques via the development of a non invasive hydration sensing patch The proposed device leverages our teamandapos s latest innovations in electrochemistry screen printing conducting polymers and surface functionalization to tender the real time profile of circulating sodium levels in a non invasive pain free fashion thereby leading to substantially improved clinical outcomes among the elderly population Expected outcomes from this research project include the development of epidermal adhesive biosensors containing a sodium ion selective layer and the ability to fabricate the said sodium biosensors employing high throughput low cost screen printing methods This agglomerates innovative techniques for the functionalization of the printed electrode contingent and relies on the development of ion selective membranes in connection with novel methods of electrochemical transduction The salient features of this epidermal biosensor platform include high sensitivity stability selectivity simplicity versatility and robustness at a price that i amenable to widespread healthcare adoption This paradigm enables the individual to take proactive measures to assess their hydration throughout their daily routine thereby mitigating the likelihood of hospital admission due to hypernatremic dehydration In addition to tendering real time feedback to the wearer this unique approach can leverage the wireless infrastructure to relay the data to the healthcare provider for review trending and archiving PUBLIC HEALTH RELEVANCE The proposed project aims to develop a skin applied transdermal sodium biosensor patch for the assessment of hydration levels This new paradigm will impart the ability to precisely track the level of hypernatremic dehydration in a non invasive real time and continuous fashion and is especially suited to the elderly population many of whom exhibit a reduced ability to perceive thirst The proposed research will substantially advance the state of the art in the geriatrics domain and will circumvent many of the limitations associated with conventional andquot skin pinchandquot hydration tests that are widely used in the clinical setting