EyeSense™: AI-Powered VOC NanoSensor Integrated Autonomous Real-Time Monitoring System for Ocular Injury Management

NanoBioFab proposes to develop and validate the EyeSense™ smart eye shield—a dual-modal, AI-powered, field-deployable diagnostic device designed for real-time, non-invasive monitoring of ocular trauma in military and austere care environments. Ocular injuries, particularly in combat scenarios, often require protective eye shields to prevent further damage. However, current protocols prohibit shield removal prior to specialist evaluation, making it impossible to detect silent yet progressive complications like infection or hemorrhage without risking additional harm. EyeSense™ addresses this diagnostic blind spot by integrating two synergistic sensing modalities into a wearable shield form factor: (1) a proprietary VOC nanosensor array for detecting infection-relevant biochemical signatures, and (2) a multi-point, non-imaging optical detector array focused on red-spectrum reflectance to monitor visual cues such as hemorrhage or inflammation. These inputs will be processed by embedded AI algorithms that provide actionable alerts (e.g., via local LED indicators or BLE output) directly on the device.The Phase II effort will (1) engineer and fabricate at least eight fully integrated prototypes using ultra-low-power electronics and military-compatible mechanical designs, (2) validate sensor performance and diagnostic accuracy in a controlled ex vivo porcine eye model simulating trauma and infection, (3) confirm longitudinal functionality and biocompatibility in a rigorous in vivo survival pig model, and (4) engage with the FDA via Q-submission to define the regulatory pathway. The device is engineered for up to 72 hours of autonomous operation, using aggressive duty cycling and COTS components to meet power and cost constraints.Expected outcomes include a TRL 5–6 validated prototype, AI models achieving ?85% sensitivity/specificity for infection/hemorrhage detection, and SOPs for preclinical and clinical transition. This system will offer transformative situational awareness to field medics and first responders, reduce iatrogenic risk, and enable earlier intervention for ocular injuries. EyeSense™ has strong dual-use potential across military, emergency, ophthalmic, and occupational care sectors where early complication detection is crucial.