First Generation of Controlled-Release Bacteriocins/Anti-Microbials

Combat ration Intermediate Moisture (IM) products currently use low pH and water content (aw) to discourage bacterial growth. The long-term goal of this SBIR project is to maintain the microbial stability of IM ration components over a three-year shelf life while increasing the pH and aw values for an improved organoleptic profile by incorporation of First Generation Controlled Release Bacteriocin/Antimicrobial (FGCRB/A). The specific objective of this Phase II application is to develop microspheres for continuous, controlled-release of antimicrobials capable of maintaining the microbial stability of IM rations with improved organoleptic characteristics after exposure to all of the relevant food manufacturing processes. This approach will provide for a safe, high-quality IM ration platform that satisfies the Warfighterfs demand for variety and palatability while reducing the amount of chemical preservatives. Orbis is uniquely qualified to achieve this objective because of our microparticle fabrication expertise, patented particle fabrication technology, and partnership with shelf-stable food experts at RDI Foods. We will also develop a cost-effective, scalable manufacturing process for bisin, the first bacteriocin effective against both gram-positive and gram-negative pathogens and incorporate this ingredient into our Phase II FGCRB/A prototype.