SBIR/STTR Research Award
Development of an in vitro assay as correlate of passive immune protection against botulinum neurotoxin to minimize use of whole animal testing
Award amount
$999,988Program and phase
SBIR · Phase IIAward year
2012Award details
- Awarding agency
- Department of Defense
- Branch
- Office for Chemical and Biological Defense
- Recipient company
- ELECTRONIC BIOSCIENCES, INC.
- Proposal award date
- 2012-05-24
- Contract end date
- 2014-09-23
- UEI
- FLHHE89XH2H5
- Solicitation number
- 2011.1
- Topic code
- CBD11-109
Research abstract
This Small Business Innovation Research project will develop a non-animal based in vitro assay for determining the efficacy of Botulinum (BoNT) neutralizing therapeutics. New technologies are currently needed in order to facilitate the development and approval of BoNT vaccines and therapies and reduce the number of vertebrate animals used in medical testing. In Phase 1 of this project, the feasibility of the proposed system was demonstrated. During Phase 2, a complete working prototype will now be built, tested and validated against the standard mouse lethality neutralization (MLN) assay. Electronic BioSciences"proposed system will be capable of monitoring the complete neutralizing mechanism of therapies to all seven BoNT serotypes, making rapid, non-animal based neutralization efficacy testing possible.
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- Rapid Fingerstick Diagnostics for Opioid and Stimulant Use Disorders
- Direct Proteolytic Machine Assessments for Unfolding and Sequencing Proteins
- High-Resolution Pseudouridine and m6A Sequencing Through Advanced Nanopore Adduct Analysis
- Fourth-Generation Nanopore-Assisted Sequencing for Advanced Oncological Analyses
- Re-Reading RNA to Obtain High Accuracy
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Development of an in vitro assay as correlate of passive immune protection against botulinum neurotoxin to minimize use of whole animal testing
- Multiplex Microsphere Assay for Botulinum Neutralizing Antibodies
Research funding history
58 SBIR/STTR records share this UEI (2007–2025). Reported award amounts total $22,847,588. Reported amounts are not federal obligations.
Phases: Phase I, Phase II, Phase II – Direct to Phase II
Agencies: Department of Health and Human Services, National Science Foundation, Environmental Protection Agency, Department of Defense, Department of Commerce