SBIR/STTR Research Award
Development of an Alternative Screening Method for Detecting Evidence of Mycobacterium Tuberculosis Infections
Award amount
$150,000Program and phase
SBIR · Phase IAward year
2012Award details
- Awarding agency
- Department of Defense
- Branch
- Defense Health Agency
- Recipient company
- TransMembrane Biosciences
- Proposal award date
- 2011-12-15
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- 2011.2
- Topic code
- OSD11-H05
Research abstract
The objective of this proposal is to develop an alternative to the tuberculin test and interferron-gamma release assays for the diagnosis of active and latent tuberculosis. Toward this end, a rapid test based on the detection of blood antibodies specific to Mycobacteria tuberculosis antigens will be devised for the serodiagnosis of active and latent TB. Selected and highly immunogenic antigens encoded in regions of difference in the genome of M. tuberculosis will be prepared. The recombinant antigens will be evaluated for possible usage in such a test by screening them with TB serum collections through ELISAs. The recombinant antigens subsequently will be used to create prototypes for further evaluation during Phase II and III.
Technology keywords
Not reported
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Development of a field-appropriate biosensor for detecting Mycobacterium tuberculosis infection
- Development of an Alternative Screening Method for Detecting Evidence of Mycobacterium Tuberculosis Infections
- Development of a Multiplexed Antigen Screening Platform for Detecting Evidence of Mycobacterium Tuberculosis Infections
- Raman Iron Biomarker RIB4TB
- The PACeR Gold - Multiplex Pathogen Identification Platform for Detection of Mycobacterium Tuberculosis Infections.