Ocular Topography Mapping

Prosthetic replacement of the ocular surface ecosystem (PROSE) is a pioneering treatment developed by the Boston Foundation for Sight to restore vision, support healing, reduce symptoms, and improve quality of life for patients suffering with complex corneal disease. Fitting the PROSE requires time-consuming custom designing because technology to automatically and accurately measure ocular surface topology is currently not available. To address the OSD-DHP need for the development of automated ocular prosthetic fitting technology, Physical Optics Corporation (POC) proposes to develop a new Ocular Topography Mapping (OCTOMAP) device, based on ultrahigh-resolution line-scan optical coherence tomography (OCT) optimized specifically for rapid measurement of the corneal and scleral surface. The innovation in the optical design of the OCTOMAP system will enable it to rapidly map the topography of the entire ocular surface. As a result, this system offers the capability to simplify and accelerate the ocular prosthetic fitting procedure, which directly addresses the OSD requirements. In Phase I, POC will demonstrate the feasibility of the OCTOMAP by assembling and testing a benchtop prototype. In Phase II, POC plans to develop a fully functional ocular surface scanner and demonstrate its performance with human subjects