Archive of Samples for Long-term Preservation of RNA and Other Nucleic Acids

The objective is to develop approaches are sought for sample preservation of nucleic acids from blood products or other sample for storage at room temperature conditions. The goals of the project are to: 1) determine preferable tissue for nucleic acid archiving; 2) investigate sample collection protocol, processing, of the selected tissue; and 3) initially define key potential aspects of storage conditions for preservation of nucleic acids. In addition, we will develop a completely integrated ambient temperature workflow from collection, transport to storage to avoid any cold-chain handling. This complete ambient workflow can be achieved through the integration of advanced thermo-stability products currently in Biomatrica's product development pipeline. The overall objective is the development of workflow which protects nucleic acids, in particular RNA from degradation during collection to sample archiving and determine its feasibility for large scale implementation.