Ultrasound for neuromodulation and control of post-trauma pain

The objective of this proposal is to demonstrate the feasibility of using ultrasound induced neuromodulation to manage pain. SynSonix, LLC has been developing ultrasound neuromodulation (UNMOD) to noninvasively stimulate neural circuitry. Many studies have established the beneficial effects of neurostimulation for managing pain. However current methodologies require surgical implantation of stimulating electrodes which is an impractical solution for acute traumas. Pain management for acute traumas is generally accomplished with narcotics, which is less than ideal in a battlefield scenario as they severely effect cognitive abilities and have other unwanted side effects such as respiratory depression. Our technology of peripheral ultrasound neuromodulation (PUNMOD) offers several advantages over narcotics and current methods of neurostimulation. PUNMOD has the potential to be highly portable as a battlefield analgesic and has the advantage of leaving the patients cognitive abilities intact. In addition PUNMOD does not carry with it the risk of abuse or the need for the surveillance that is associated with pharmaceutical analgesics. In this proposal we outline a plan for the development and testing of a portable, first-generation prototype capable of noninvasive peripheral neurostimulation to modulate pain.