Software Tool for Complex Biomarker Discovery

A new algorithm is proposed to identify hazards based on high-fidelity correlation between gene expressions and pathway signals. A software implementation based on'energy score'method has been developed to detect multiple gene interactions in the pursuit of specific signal pathways within key cells of interest. This method, Graphical Random Walk (GRW) is robust, highly sensitive, and unlike methods of binary descent, can detect very low continuous exposures. Proof of feasibility and the application of this methodology toward monitoring for toxic threats and exposures will provide the US Army with a significantly improved defense against short term and long term threats.