SBIR/STTR Research Award
Assessment of Protective Properties of Optimized Flagellin Derivative Against Biologically Harmful Effects of Ionizing Irradiation During Space Flight
Award amount
$99,589Program and phase
STTR · Phase IAward year
2006Award details
- Awarding agency
- National Aeronautics and Space Administration
- Branch
- Not reported
- Recipient company
- Cleveland Biolabs, Inc
- Proposal award date
- 2006-01-24
- Contract end date
- 2007-01-22
- UEI
- J223MEGF2LP1
- Solicitation number
- Not reported
- Topic code
- T1.02
Research abstract
The goal of this proposal is to explore a novel proprietary biopharmaceutical agent, named deltaFL-AA', a first in the series of innovative radioprotectors to act as an agent providing protection of the organism against major space radiation risks. These risks include organism death resulting from acute irradiation as well as radiation-induced carcinogenesis caused by low-dose exposure. An unprecedented radioprotective potency of deltaFL-AA' demonstrated by its ability to cure 100% of mice from supralethal (14 Gy) doses of gamma-irradiation and its strong immunostimulatory properties (especially the ability to trigger natural killer response, which is well established as one of the antitumor firewalls) make this drug an extremely attractive candidate for testing in a NASA-funded program.
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- RADIOPROTECTORS TARGETING P53
- N-myc Targeted Therapeutics for Childhood Neuroblastoma
- RADIOPROTECTORS TARGETING P53
- Effective Radioprotectants Targeting Toll-like Receptor 5
- Bacterial Proteins as Cancer Drugs and Radioprotectors
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Transient Acoustic Environment Prediction Tool for Launch Vehicles in Motion during Early Lift-Off
- Multiphase Modeling of Solid Rocket Motor Internal Environment
- Multiphysics Framework for Prediction of Dynamic Instability in Liquid Rocket Engines
- A Massively Parallel Framework for Low-Dissipation, Multiphysics Simulations of Rocket Engines
- High Performance Simulation Tool for Multiphysics Propulsion Using Fidelity-Adaptive Combustion Modeling
Research funding history
11 SBIR/STTR records share this UEI (2004–2007). Reported award amounts total $2,269,549. Reported amounts are not federal obligations.
Phases: Phase I, Phase II
Agencies: Department of Health and Human Services, National Aeronautics and Space Administration