Physiological Signal Analyzer for Continuous Monitoring of Changes in Pulse Pressure, Heart Rate Variability, and Baroreflex Sensitivity

To enhance the survivability of injured and wounded soldiers, the U.S. Army requires a portable, noninvasive device for continuous monitoring of changes in pulse pressure, heart rate variability and baroreflex sensitivity. Physical Optics Corporation (POC) proposes to develop a new Physiological Signal Analyzer (PSA) for continuous monitoring of Pulse Pressure Variation (PPV), Heart Rate Variability (HRV), and Baroreflex Sensitivity (BRS) to meet that need. Our PSA design is based on noninvasive electrocardiogram sensors and photoplethymograph, combined with wireless technology for real-time monitoring of patient status by acquiring, processing, recording, and analyzing data. With continuous real-time data provided by the PSA, the first responder will have an earlier indication of injury severity and patient status. In addition to use in prognosis and triage, the PSA generates an alarm signal if patient status begins to deteriorate and immediate life-saving intervention is necessary. Compact, lightweight, battery-powered, and easy to use, the PSA system is suitable for conditions from base hospital to remote battlefield. In Phase I POC will demonstrate PSA feasibility by developing a laboratory prototype. In Phase II POC plans to build a preproduction prototype and to test its performance in hospital trauma centers.