Analysis Tools for Detection and Diagnosis of Biological Threats

DNA microarray technology, in combination with statistical and predictive modeling tools, could be used to evaluate thousands of genes against distinct gene expression patterns induced by chemical/biological agents to provide early identification and speed therapeutic intervention. The overall objective of this Phase II effort is to leverage existing public domain resources and commercial tools to provide the Army with a comprehensive data management system with integrated statistical and pattern recognition tools capable of: 1) Identifying agent specific gene profile biomarker signatures; 2) Teasing out exogenous factors such as ingested food, stressors, etc.; 3) Discriminating naturally occurring diseases from weaponized biological agents; and 4) Linking gene expression responses to physiological responses. Similar needs for a data management system with statistical and visualization tools exists in the private sector, specifically basic research and the pharmaceutical industry. The secondary objective of Phase II is to develop a product that meets private sector needs as well as those of the Army. At the conclusion of Phase II, Alpha-Gamma will have a product (bioCAT) ready for commercialization in the private sector.