Developing Bioinformatics Tools for Proteomics Research

We propose to develop an analytical system for import, visualization and comprehensive network analysis of proteomics data. Proteomics data will be integrated with other datasets relevant for the same biological system, and compared in the framework of biological networks. The system will be based on our existing comprehensive database of human protein-protein interactions MetaBase, the toolkit for visualization and computational analysis of biological networks MetaCore and the medicinal chemistry tool MetaDrug. The new platform will be capable of recognition and incorporation of proteomics data of different formats and aligning them with microarrays gene expression, DNA sequences, metabolomic data and human diseases. On the next step, we will develop and validate algorithms and methodology for identification of biological networks from the assembled data. When developed, the new platform will have a broad range of applications in drug discovery, bio- and chemical defense and academic research in several disciplines.