Self-Assembling System for Targeted Nanodelivery of Proteins (STOP)

The proposed program presents a novel approach to the design of a biocompatible, biodegradable, non-toxic, water-soluble nanodelivery system, that allows for the stabilization of proteins and for delivery in a controlled manner. Conflicts in recent world history have seen an influx in the usage of untraditional munitions by groups and nations aiming to press their agendas against the will of the international community. Such parties pose immediate and long-term threats to the defense and security of the American people, thus substantiating the importance of research aimed at the development of a Self-Assembling System for Targeted Nanodelivery of Proteins (STOP) to protect deployed personnel from biological agents, such as anthrax. In the Phase I Base program, STOP development will focus on the preparation and characterization of nanocapsules capable of preserving the activity of antibodies to the protective antigen. The program will focus on developing a method of deposition of the antibodies into the carrier system and determining the release rate and activity of the incorporated antibodies. The Option program will involve scale-up and evaluating the stability of the nanoencapsulated antibodies and the rate of its release in human plasma. (P-040588)