ECIS Wound Healing High-Throughput Assay

Healing of a wound is a complex and protracted process of tissue repair and remodeling in response to injury. Understanding how the body repairs damaged tissue and what genes and biochemical factors influence the wound healing process will have tremendous impact on the treatment of chronic wounds and the regeneration of tissue and organ function after injury. To facilitate the discovery of genes and compounds that are involved in wound healing, Agave BioSystems will develop an in vitro cell based system that will allow high-throughput analysis of genes and chemical compounds that may have a therapeutic affect in wound healing. This high-throughput, in vitro, wound healing assay will utilize small interfering RNA to specifically interfere with the function of genes of interest and Electric Cell-Substrate Impedance Sensing (ECIS) to non-invasively monitor the kinetics of fibroblast and epithelial wound healing.