Non-Invasive Glucose Monitoring Using Low-Coherence Interferometry

This project proposes a method for non-invasive glucose monitoring based on the analysis of changes in skin light scattering properties induced by changes of glucose levels in skin interstitial fluid. Comparing to other similar approaches, this project proposes a more accurate light-tissue interaction model, based on multiple scattering. The overall goal for Phase I is to demonstrate that the multiple scattering framework has the potential for: a) improved sensitivity and specificity of observables with respect to glucose concentration, and b) improved stability of observables vs. optical skin heterogeneities and specific point of optical contact. Optical probes will be constructed and characterized within the multiple scattering framework. Additionally, Phase I of the project will validate dynamic range improvement using instrument noise and speckle noise filtering algorithms. Phase II of the project will construct an optimized instrument for non-invasive glucose monitoring, based on the results obtained in Phase I.