LITERATURE IN THE AREA OF CHEMOPREVENTION THIS PROJECT IS THE DEVELOPMENT AND MANAGEMENT OF A COMPREHENSIVE INFORMATION RESOURCE ON CHEMOPREVENTION AND INVOLVES SURVEILLANCE OF THE SCIENTIFIC LITERATURE TO IDENTIFY NEW POTENTIAL CHEMOPREVENTIVE AGENTS

LITERATURE IN THE AREA OF CHEMOPREVENTION THIS PROJECT IS THE DEVELOPMENT AND MANAGEMENT OF A COMPREHENSIVE INFORMATION RESOURCE ON CHEMOPREVENTION AND INVOLVES SURVEILLANCE OF THE SCIENTIFIC LITERATURE TO IDENTIFY NEW POTENTIAL CHEMOPREVENTIVE AGENTS AND RELEVANT DATA ON KNOWN AGENTS, EVALUATING AND COMPILING THE DATA INTO A COMPUTERIZED DATABASE AND APPLYING THE INFORMATION IN THE DATABASE TO THE PRIORITIZATION OF AGENTS AND TO OTHER R&D PROBLEMS IN CHEMOPREVENTION, AS NEEDED BY THE NATIONAL CANCER INSTITUTE (NCI). THE DEVELOPMENT OF CHEMOPREVENTIVE AGENTS IS A HIGH PRIORITY RESEARCH EFFORT AT NCI, PARTICULARLY FOR AGENTS THAT ARE EFFICACIOUS AND SAFE FOR USE IN PATIENTS AT HIGH RISK FOR DEVELOPING CERTAIN TYPES OF CANCERS. IN PHASE II, THE DATABASE WILL CONTINUE TO BE EXPANDED BUT EMPHASIS WILL BE PLACED ON APPLICATIONS OF THE INFORMATION RESOURCE TO R&D PLANNING SUCH AS STRUCTURE-ACTIVITY STUDIES, IDENTIFYING GAPS IN KNOWLEDGE, ESTABLISHING TESTING PRIORITIES, AND EVALUATING THE RELIABILITY OF VARIOUS SCREENING METHODOLOGIES. SIMILARLY, THIS INFORMATION RESOURCE SHOULD BE USEFUL IN R&D PLANNING FOR COMMERCIAL COMPANIES INTERESTED IN DEVELOPING CHEMOPREVENTIVE AGENTS.