SBIR/STTR Research Award
HAMSTER OVARY CELLS IN RESPONSE TO PRESENT CONCERNS REGARDING THE EFFICACY OF THE L5178Y MOUSE LYMPHOMA CELL MUTAGENESIS ASSAY (MLA) AT THE TK LOCUS, THERE ARE NEEDS TO EXAMINE FURTHER THE HYPOTHESIS THAT THE PRESENCE OF SMALL MOUSE LYMPHOMA COLONIES IN
Award amount
$50,000Program and phase
SBIR · Phase IAward year
1985Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- Genesys Research, Inc.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
HAMSTER OVARY CELLS IN RESPONSE TO PRESENT CONCERNS REGARDING THE EFFICACY OF THE L5178Y MOUSE LYMPHOMA CELL MUTAGENESIS ASSAY (MLA) AT THE TK LOCUS, THERE ARE NEEDS TO EXAMINE FURTHER THE HYPOTHESIS THAT THE PRESENCE OF SMALL MOUSE LYMPHOMA COLONIES IN A BIMODAL DISTRIBUTION OF COLONY SIZES IS CORRELATED WITH THE PRESENCE OF CHROMOSOMALLY ABERRANT CELLS AND TO DETERMINE WHY CHEMICALS THAT ARE MUTAGENIC IN THE MLA HAVE FAILED TO PRODUCE CHROMOSOMAL ABERRATIONS IN CHINESE HAMSTER OVARY (CHO) CELLS. IN ORDER TO DEMONSTRATE THE FEASIBILITY OF THIS RESEARCH AND THE LABORATORY'S CAPABILITIES, PHASE I EFFORTS WILL BE DIRECTED PRIMARILY TOWARD USING A MORE SENSITIVE CYTOGENETIC ASSAY PROTOCOL TO EXAMINE CHROMOSOMAL ABERRATION FREQUENCIES IN MOUSE LYMPHOMA AND CHO CELLS EXPOSED TO 6 CHEMICALS THAT ARE MUTAGENIC IN THE MLA BUT NEGATIVE IN THE CHO CHROMOSOMAL ABERRATION ASSAY. THESE RESULTS WILL BE COMPARED WITH THE DISTRIBUTIONS OF COLONY SIZES FROM MLAS OF THE SAME 6 CHEMICALS.
Technology keywords
Not reported