THE LONG TERM OBJECTIVE OF INTRON, INC.

THE LONG TERM OBJECTIVE OF INTRON, INC. IS TO DEVELOP, MANUFACTURE AND MARKET A PROCUCT LINE OF ANTIGEN/ORGANISM SPECIFIC TRANSFER FACTORS (TF; AN IMMUNE POTENTIATOR) WITH APPLICATION FOR IMMUNOPROPHYLAXIS AND IMMUNOTHERAPY OF A WIDE VARIETY OF HUMAN VETERINARION DISEASES FOR WHICH A STRONG DEPENDENCY ON THE DEVELOPMENT CELL MEDIATED IMMUNITY HAS BEEN DOCUMENTED FOR HOST PROTECTION. TO ACCOMPLISH THIS OBJECTIVE, INTRON, INC. INTENDS TO DEVELOP ORGANISM/ANTIGEN SPECIFIC TRANSFER FACTORS BY IMMUNIZING PREGNANT DAIRY COWS. INTRON, INC. SCIENTISTS HAVE DEMONSTRATED THAT COWS WITH PRE-EXISTING CELLULAR IMMUNE RESPONSIVENESS TO CERTAIN MICROORGANISMS WILL HARBOR TF'S SPECIFIC FOR THESE ORGANISMS IN POST-PARTURITION COLOSTRUM (AND MILK). COLOSTRUM POTENTIALLY REPRESENTS AN INEXPENSIVE RICH SOURCE OF TF. IT IS NOT KNOWN, HOWEVER, WHEN OR BY WHAT ROUTE A COW MUST BE IMMUNIZED IN ORDER TO INDUCE THE ACCUMULATION OF A PARTICULAR ORGANISM SPECIFIC TF IN COLOSTRUM. PHASE I RESEARCH WILL ADDRESS: (A) THE IMMUNIZATION ROUTE TO BE USED, AND (B) THE NUMBER OF IMMUNIZATIONS AND THEIR TEMPORAL RELATIONSHIP TO PARTURITION. IN PHASE II, INTRON, INC. WILL EMPLOY THE INFORMATION OBTAINED FROM PHASE I TO BULK PRODUCE CERTAIN TF'S IN BOVINE'S FOR USE IN DOUBLE-BLIND CLINICAL TRIALS TO DOCUMENT THE EFFICIENCY OF THIS IMMUNE POTENTIATOR IN SELECTED HUMAN AND VETERINARIAN DISEASES WHICH HAVE A MAJOR SOCIO-ECONOMIC IMPACT.