Cell Synchronization to Aid Scale up of mAB Production

Monoclonal antibodies (mABs) have been instrumental in many major advances in our understanding ofdiseases, hypoimmune disorders, hyperimmune disorders and carcinogenesis. MAbs have progressively imlaboratory diagnosis of infectious and immune diseases; they also greatly aid diagnosis, prognosticamalignant diseases. More recently mAbs have lead to FDA approved in vivo diagnostics. Currently mAbsnumerous clinical and preclinical trials as in vivo therapeutics. Numerous medically, scientificallyimportant products are mAbs. Production of mAbs is thus of major importance. Nevertheless our abilithybridoma growth and our understanding of the relationship between hybridoma growth and mAb productiThese studies examine the ability of a regulator of cell growth (CeReS) to control the reproductionsynchronize their metabolic activity and stimulate the production of mAbs. CeReS reversibly holds cecircumstantial data in other systems indicate that cells in G1 produce more mAb. These studies willcycle dependence of mAb production, 2) provide researchers and manufacturers methods to turn cell rewithout altering nutrient supply or applying toxic drugs and 3) dramatically increase mAb production