Live Vibrio Cholera as an Oral SIV Vaccine Vector

Vibrio cholera is a human pathogen that colonizes the gut and elicits both mucosal and systemic proresponses. Novel SIV prophylactics will be developed using a genetically attenuated strain of this oSIV vaccines. These new oral vaccines will be evaluated in animals for their immunogenicity. As a coCollaborative Mucosal Immunology Group for AIDS vaccine (CMIG, AI35544), these vaccines will be evalprimates for their immunogenicity and protective efficacy using the SIV primate model. This study widatabases for developing HIV prophylactics and for conducting human trials. Considering the disastropopulation in developing countries in Africa and in Asia, effective and inexpensive oral HIV1 vaccinto stop the AIDS pandemic.