SBIR/STTR Research Award

Isolation of Proteolytic Antibodies in E Coli

Award identifier 8d581ccb57f5276b946791040450b6941889baa91c3e91907f8baa6e95f64813Awarding agency Department of Health and Human Services

Award amount

$49,347

Program and phase

SBIR · Phase I

Award year

1993

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Award details

Awarding agency
Department of Health and Human Services
Branch
Not reported
Recipient company
STRATAGENE
Proposal award date
Not reported
Contract end date
Not reported
UEI
Not reported
Solicitation number
Not reported
Topic code
Not reported

Research abstract

The objective is to isolate antibody molecules capable of proteolytic cleavage of their cognate antigen. An E. coli selection system has been devised to identify these antibodies. Large antibody libraries can be made and screened in E. coli using the ImmunoZapTM technology. This directed approach to the isolation of rare antibodies with proteolytic activity may lead to new types of therapeutic agents for combating certain infections and diseases.

Technology keywords

Not reported

Agency intelligence

Department of Health and Human Services

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