ISOLATION OF APTAMERS FOR AFFINITY CHROMATOGRAPHY

Not Available The proposed Phase I SBIR program provides a means of analyzing and extending current methods of gathering simulator and in-flight assessments of helicopter flight tasks and maneuvers through application of task performance math models. The program employs innovative research in the areas of pilot modeling, rotorcraft inverse simulation modeling, pilot-vehicle-task analysis, and simulation. Sample tasks obtained from recent piloted simulations are analyzed to develop the important pilotage-task metrics, workload effects, safety considerations, and vehicle dynamic relations. The objectives include assembly of existing math model software for off-line simulation of ADS-33 helicopter pilot-vehicle-task models, validation of derived models, construction of two compelling task model examples, demonstration of variation for pre-simulation or pre-flight study and application of inverse simulation methodology. Project tasks to follow these objectives in order, and conclude with an outline for advanced software needs leading to a Phase II study. Phase II would extend the methodology to new tasks and classes rotorcraft, extend to all axes of control and environmental conditions, and acquire needed simulator or in-flight validation data. Results of the SBIR Phases I and II extend both to military and commercial applications in engineering research and development as well as aircrew training and flight safety. BENEFITS: Provides means for augmenting conventional simulator and in