SBIR/STTR Research Award
Defining T cell epitopes in Dengue virus infection
Award amount
$299,998Program and phase
SBIR · Phase IAward year
2007Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- IMMUNOTOPE, INC.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
DESCRIPTION (provided by applicant): Dengue Fever (DF) and Dengue Hemorrhagic Fever (DHF) are significant global public health problems and understanding the overall immune response to infection will contribute to appropriate management of the disease and its potentially severe complications. Live attenuated and subunit vaccine candidates induce primarily an antibody response to the virus, which is not only ineffective, but potentially deleterious. Currently, there are no available tools to assess the protective T cell responses during infection or post vaccination. The primary objective of this project is to create new informational and diagnostic tools to characterize T cell immunity in DV infection for vaccine validation and potentially develop new, effective and protective vaccine strategies.
Technology keywords
Not reported