SBIR/STTR Research Award

Fluorescent Indicators for Cytosolic Lithium Ion

Award identifier c671d33d2f261224fb68265f9cf32577890ca9132a80c6db6fada5c484be49f8Awarding agency Department of Health and Human Services

Award amount

$50,000

Program and phase

SBIR · Phase I

Award year

1993

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Award details

Awarding agency
Department of Health and Human Services
Branch
Not reported
Recipient company
COVALENT ASSOC., INC.
Proposal award date
Not reported
Contract end date
Not reported
UEI
Not reported
Solicitation number
Not reported
Topic code
Not reported

Research abstract

We propose to synthesize and test new fluorescent indicators for the lithium ion in aqueous solution. The indicators are designed to be water soluble and to respond selectively to Li+ by undergoing a shift in absorption and emission wavelengths. The proposed compounds will be of primary interest for determining the concentration of cytosolic Li+ and for monitoring any flux of Li+ in single cells acted on by neurotransmitters. The indicators will be of use to cell physiologists and neuroscientists studying the influence of Li+ on the phosphatidylinositol cycle implicated in the mechanism by which Li+ functions in the treatment of manic-depressive psychosis. The indicators may also be of use for measuring the concentration of Li+ in the serum of patients undergoing therapy.

Technology keywords

Not reported

Agency intelligence

Department of Health and Human Services

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