SBIR/STTR Research Award
INSTRUMENTATION FOR DNA SEQUENCING
Award amount
$49,947Program and phase
SBIR · Phase IAward year
1992Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- Interferometrics, Inc.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
WE WILL DEVELOP A NOVEL TECHNIQUE FOR CONSIDERABLY INCREASING THE SPEED AND EFFICIENCY OF DNA SEQUENCING. THIS TECNIQUE IS BASED ON MULTIPLE ISOTOPIC DETERMINATION AND CAN BE EXTENDED TO ANALYSE THE OUTPUT OF OTHER FRACTIONATION PROCESSES, E.G. COLUMN CHROMATOGRAPHY. THE SYSTEM: (1) IS FULLY AUTOMATED, (2) PERMITS MULTI-ISOTOPE IMAGING, (3) PROVIDES SIZE AND SPATIAL RESOLUTION COMPARABLE TO NUCLEAR EMISSIONS, AND (4) AFFORDS QUANTUM DETECTION EFFICIENCY ORDER OF MAGNITUDE BETTER THAN "AUTORADIOGRAPHY". THE USE OF 15 ISOTOPES OF BROMINE/IODINE PROMISE ORDERS OF MAGNITUDE ACCELERATION OF ANALYTICAL PROCEDURES USED NOT ONLY IN DNA SEQUENCING, BUT ALSO IN HUNTING FOR GENES RESPONSIBLE FOR GENETIC DISEASE.
Technology keywords
Not reported