Improved Cervical Cancer Therapy

Experimental results suggest that cell regulatory sialoprotein (CeReS), a natural inhibitor of cellused to qualitatively distinguish the cells from certain cancers and normal cells. This may facilitanon-toxically holds normal cells in G1 while the cancer cells divide. Thus it is believed that normaCeReS will be protected from chemotherapies specific for S, M or G2 while the cancer cells will be kthis work is to test this hypothesis. Both recent understanding of carcinogenesis and the mechanismsuggest this approach is feasible. It is currently believed that many human cancers have enhanced abmultiply because they lack functional product of the retinoblastoma (Rb) gene. Normal cells have thidivision. CeReS is believed to act by maintaining the Rb protein in a hypophosphorylated form. Thistranscription factors necessary to make proteins required for cell division. Thus CeReS prevents norThose cancers which have eliminated this normal regulatory method (and thus have increased capacityinhibited by CeReS. This difference may allow specific killing of cancer cells.