SBIR/STTR Research Award
Affinity reagents for the detection of modified RNAs and Transcriptome-wide mapping of RNA modifications
Award amount
$209,008Program and phase
SBIR · Phase IAward year
2014Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- GUILD ASSOCIATES INC
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- G1RKNNXESY18
- Solicitation number
- DA15-001
- Topic code
- NIDA
Research abstract
DESCRIPTION (provided by applicant): Biological RNAs undergo extensive post-transcriptional modifications. These modifications are important in promoting the accuracy and efficiency of gene expression in biological systems. To decipher the functions of RNA modifications, robust analytical tools and methods that enable scientists to monitor, manipulate, and transcriptome-wide mapping RNA modifications are highly needed. In this multi-phase SBIR program, Guild Biosciences Inc. (GBS) proposes to address thisissue by: 1) developing a library of affinity antibodies and peptide sequences specific to modified nucleosides by using phase-antibody display libraries and peptide phase-display library, 2) developing a novel immunoassay system- open immunocomplex assaywith the developed antibodies and peptides for rapid and quantitative detection of modified nucleotides in RNA samples, and 3) incorporating the immunoprecipitation capability of the developed affinity reagents with next-generation sequencing platform
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- Improved Anerobic Digester Biogas Production through the Application of Immobilized Enzymes
- SBIR PHASE I (NIMH TOPIC 3): POINT-OF-CARE AND PHARMACY-BASED ANTIRETROVIRAL DRUG ADHERENCE ASSAYS - POINT-OF-CARE ANTI-RETROVIRAL DRUG ADHERENCE IMPEDANCE SPECTROSCOPY DEVICE
- NIMH SBIR PHASE I TOPIC 001- POINT-OF-CARE HIV VIRAL LOAD AND DRUG ADHERENCE ASSAYS HIV, pre-exposure prophylaxis, antiretroviral therapy, electrochemistry, impedance spectroscopy, viral load, point of care, sensor
- Immobilization of Enzymes for Enhanced Production of Protein Hydrolysate and Lactose Free Products from Whey
- POINT-OF-CARE ELECTROCHEMICAL APTASENSOR FOR LONG-TERM PHARMACOLOGICAL ADHERENCE MONITORING
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Wearable Wireless Respiratory Monitoring System that Detects and Predicts Opioid Induced Respiratory Depression
- Building and testing the Life Enhancement and Advocacy Programming digital training tool (LEAPLink) to better serve people with lived experience of homelessness and substance use disorder
- A digital intervention to decrease self-stigma among pregnant and postpartum women with opioid use disorder
- Development of medication for the treatment of respiratory depression due to opioid (prescribed or illicit) overdose/multidrug (polysubstance) overdose in a hospital or community setting.
- Creation and Validation of the Dose-Opioid-Source Evaluation tool (DOSE) - a Robust Opioid Use Clinical Outcome Assessment for Qualification as an FDA Medical Device Development Tool (MDDT)
Research funding history
72 SBIR/STTR records share this UEI (1983–2025). Reported award amounts total $19,817,804. Reported amounts are not federal obligations.
Phases: Phase I, Phase II
Agencies: Department of Defense, Department of Health and Human Services, National Science Foundation, Department of Agriculture, Environmental Protection Agency, Department of Commerce