SBIR/STTR Research Award
Automated 3D quantitative analysis of dendritic spines imaged with light microsco
Award amount
$349,878Program and phase
SBIR · Phase IAward year
2012Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- MICROBRIGHTFIELD, LLC
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- L5XGENY3LNN7
- Solicitation number
- PA10-050
- Topic code
- NIMH
Research abstract
DESCRIPTION (provided by applicant): In this Lab to Marketplace proposal, we aim to develop the MBF SpineStudio software incorporating the innovative, laboratory-based NeuronStudio software created at the Mount Sinai School of Medicine. Our SpineStudio software will enable automated detection, reconstruction and morphological classification of the structural analysis of dendritic spines. By creating this commercial software, we will improve the existing technology by providing validated, supported, and fully-documented software for automated 3D quantitative dendritic spine analysis. This software will integrate the specific advantages of the NeuronStudio software for a combination of neuron labeling, imaging (including in vivo), and image pre- processing techniques applied by the user without requiring expert knowledge in software programming. The software product will offer automated detection, reconstruction, and separate classification of complex spines (cup-shaped, multi-headed or branched, filopodia). Providing this innovative functionality will help research in important fields such as neurodegenerative diseases, learning, and memory. PUBLIC HEALTH RELEVANCE: Structural changes that occur in dendritic spines, the smallest element of neuronal anatomy, are hypothesized to underlie the processing and storage of information. Thus, dendritic spines have become a central target in research focusing on learning and memory and, in particular, on the prevention of cognitive decline in neurodegenerative diseases. Our proposed SpineStudio software will enable automated detection, reconstruction and morphological classification of the structural analysis of these dendritic spines. By creating a commercial product, incorporating the innovative NeuronStudio software, this will accelerate the pace of discovery and understanding of dendritic spines research by providing a reliable, robust and fully-supported research tool that is fully validated and continually developed.
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- Microscope system for large scale optical imaging of neuronal activity using kilohertz frame rates
- System for Volumetric 2-photon Imaging of Neuroactivity Using Light Beads Microscopy
- Next generation axonal quantification and classification using AI
- System for Volumetric 2-photon Imaging of Neuroactivity Using Light Beads Microscopy
- Microscope system for large scale optical imaging of neuronal activity using kilohertz frame rates
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Anise Health: Digital Mental Health for Asian Americans
- iKinnect2.0 for Juvenile Justice Involved Youth at Risk for Suicide Diversity Supplement
- The Development and Systematic Evaluation of an AI-Assisted Just-in-Time-Adaptive-Intervention for Improving Child Mental Health
- Scalable, non-dissociative single-cell RNA sequencing for mapping the brain in health and disease
- A MEMS-Based High-Throughput Photostimulation Device with Commercial Backplane Integration
Research funding history
42 SBIR/STTR records share this UEI (1989–2023). Reported award amounts total $42,106,779. Reported amounts are not federal obligations.
Phases: Phase I, Phase II, Phase II – Direct to Phase II
Agencies: Department of Health and Human Services, Department of Defense, National Science Foundation