Rapid Microfluidic Production of Multiple PET Biomarkers

78966S The DOE has expressed a need for novel probes for biomedical applications as well as radio tracers for functional molecular imaging. Synthesis of novel probes and radiotracers, particularly new PET biomarkers, is difficult and costly and is limiting the utility of PET imaging technology. There is a need for rapid production of multiple and novel biomakers with PET radiolabels from a single synthesis device, which can be routinely operated by clinical and research staff. This project will develop a microfluidic platform for high speed organic synthesis and flow-based purification of PET biomarkers, with closed-loop feedback for continuous yield optimization. The device will be capable of producing multiple biomarkers in less than 60 seconds by operating in parallel with interchangeable cartridges. Only microliter quantities of reagents will be consumed and minimal user setup will be required. In Phase I, the microfluidic circuit will be designed to support closed-loop production of biomarkers with [F-18] fluoride ion labels. A prototype synthesis platform will be fabricated, characterized, and used to synthesize fluorodeoxyglucose (FDG) as a demonstration of feasibility. Commercial Applications and Other Benefits as described by the awardee: The microfluidic synthesis platform should enable PET researchers to rapidly synthesize and optimize new biomarkers while consuming only microliter quantities of costly reagents. The same device can transition from research to clinical biomarker production, leveraging fast reaction speed and low reagent costs to deliver new and more specific biomarkers at significantly lower costs compared to conventional automated chemistry. Sterile disposable reactor and reagent cartridges should provide a recurring market as well.