SOLID PHASE SYNTHESIS OF A COMBINATORIAL LIBRARY

Solid Phase Sciences Corporation (SPSC) proposes to produce a library of substituted acridine and pyridine based heterocycles. The library will consist of 5-10 milligrams each of a total of 384 compounds. SPSC will accomplish this by utilizing it's novel high-loading support and commercially available solvent delivery robot. Specifically, libraries will be made off of this high-loading support to separate the desired products from undesired starting material. A liquid handling robot will be used to add reagents and solvents. The goal of the Phase I effort will be to integrate the use of this high-loading support in solid phase synthesis with automated liquid handling into one automated system to produce a library composed of a series of acridine and pyridine based heterocyclic compounds for general screening. $ = TOTAL AWARD AMTS & NOT LIMITED TO PORTION OF PROJECT RELATED TO SUBJECT OF SEARCH SUBPROJECT $ = TOTAL AWARD AMOUNT DIVIDED BY NUMBER OF SUBPROJECTS SOURCE: CRISP FORMAT F FY 97 LAST UPDATE 04-07-98 1QUERY 1536 ID SEARCH 06/01/98 PAGE 153 --PROJECT NUMBER......1 R43 CA72414-01A1 INVESTIGATOR NAME/ADDRESS FY 97 BURDETTE, EVERETTE C IRG/INTRAMURAL UNIT..ZRG7 BURDETTE MEDICAL SYSTEMS INC AWARD AMOUNT......... $99,924 2115 SEATON COURT CHAMPAIGN, IL 61821 PERFORMING ORGANIZATION: BURDETTE MEDICAL SYSTEMS, INC. TITLE REAL TIME 3-DIMENSIONAL BRACHYTHERAPY GUIDANCE SYSTEM ABSTRACT: A technique is proposed for the development of a real-time, 3- dimensional ultrasound-based visualization system for guidance of radioactive implants for treating prostate cancer. The system includes a real-time 3 dimensional imaging array and supporting 2D, 3D, and virtual reality visualization interfaces. Present techniques using transrectal ultrasound guidance for brachytherapy result in unacceptable rates of complication. The aim of the proposed technique is to reduce the complication rates and improve the local control rates by optimizing the visualization of seed implantation during ultrasound-guided brachytherapy.