Diagnostic Antigens of Trypanosoma Cruzi

We will produce and apply antigenic peptides of the protozoan parasite, Trypanosoma cruzi.This parasite is a major cause of heart disease in Latin America, with an estimated 18 million personsinfected. These peptides would form the basis for a serodiagnostic test used to screen blood suppliesin developed and developing countries where this parasite is endemic or has been imported. Severalthousand cases of transfusion-acquired infections with this parasite occur each year, and the potentialfor millions has been reported. No defined antigens are currently in use, making available tests expensiveand inaccurate. The studies will lead to an inexpensive, reliable, and standardized test with a very largemarket potentia. The studies will benefit from progress already made and from a well establishedcollaboration with investigators in developing countries.