A Versatile SprayPaint Biosensor for the Modern BioDefense Threat Environment

Solus Biodefense Proposes Phase II Development of a Novel DNA Aptamer-Polymer Conjugate as the Primary Component of a Spray Paint Sensor Intended for Ultrasensitive and Versatile Hardware-Independent Detection of Biological Threat Agents. The MolecularSensor Biotechnology Couples Aptameric 'Antibodies of the Future' with a Synthetically-Modified Laser and RF-Excitable Luminescent Biopolymer Capable of Transducing BWA-Specific Molecular Target Detection via Modulation of Aptamer-Polymer ConjugateEmission Patterns. Aptameric Biotechnology is Expected to Yield an up-to-10,000 Fold Improvement in Detection Sensitivity over Existing Antibody and Gene Probe Based Approaches. Based on Proof of Concept Results Obtained in Phase I, Further Development andMaturation of Synthetic Derivatization Chemistries is Proposed for the Purposes of Achieving Commercially Feasible Preparation of Spray Paint Sensor DNA Aptamer-Polymer Conjugates. Additional Innovation of Multi-Target Multiplex Detection Capabilities atCovert Wavelength Optical Signaling Bandwidths is Incporated in the Design, as is Implementation of Spray Templates and Emission Pattern Recognition Techniques for Rapid Field Application of Sprayed MicroArrays to BWA Suspect Surfaces. An Additional UniqueFeature of the Proposed Phase II Effort is the Application of Automated Robotic MicroArray Technology to BWA-Specific Detection and Interdiction Aptamers, a Future Direction That Presents Extensive Commercial Opportunity.