ELECTRONIC BIOSENSORS FOR IMMUNOASSAYS: A SURFACE CONDUCTANCE APPROACH

THERE IS A LARGE POTENTIAL MARKET FOR BIOSENSORS IN THE CLINICAL AND HEALTH CARE FIELDS AND FOR INDUSTRIAL PROCESS MONITORING. OFTEN BIO-SENSORS REQUIRE EXPENSIVE EQUIPMENT AND PROCEDURES THAT ARE CONFINED TO THE SKILLED OPERATOR ANDTHUS ARE UNSUITABLE FOR MANY PURPOSES OUTSIDE THE ANALYTICALLABORATORY. A NOVEL SIGNAL TRANSDUCTION METHOD IS DESCRIBEDTHAT COULD LEAD TO SIMPLIFIED MONOCLONAL ANTIBODY-BASED IMMUNOSENSORS. THIS APPROACH IS ORIENTED TOWARDS A TECHNIQUE THAT MEASURES CHANGES IN RESISTANCE THAT OCCUR IN ULTRA-THIN METAL FILMS WHEN AN ANTIBODY-ANTIGEN INTERACTION TAKES PLACE AT THE THIN-FILM SURFACE.