THROUGHPUT SCREENING TO IDENTIFY COCAINE ANTAGONISTS

DESCRIPTION: Although cocaine addiction and overdose represent a significant health problem in the United States, there is currently no available pharmacologic treatment. This Phase I proposal is aimed at testing a large number of compounds using a high throughput screening (HTS) technique to find selective cocaine antagonists or agonist/ antagonists that may be useful in treating cocaine addiction and overdose. Compounds from in vitro binding and uptake studies will be used in in vivo behavior tests to identify potentially useful compounds. $ = TOTAL AWARD AMTS & NOT LIMITED TO PORTION OF PROJECT RELATED TO SUBJECT OF SEARCH SUBPROJECT $ = TOTAL AWARD AMOUNT DIVIDED BY NUMBER OF SUBPROJECTS SOURCE: CRISP FORMAT F FY 97 LAST UPDATE 04-07-98 1QUERY 1536 ID SEARCH 06/01/98 PAGE 246 --PROJECT NUMBER......1 R43 DA11644-01 INVESTIGATOR NAME/ADDRESS FY 97 SUCHOLEIKI, IRVING IRG/INTRAMURAL UNIT..ZRG3 SOLID PHASE SCIENCES CORP AWARD AMOUNT......... $94,965 225 COOLIDGE AVE, SUITE 110 WATERTOWN, MA 02172 PERFORMING ORGANIZATION: SOLID PHASE SCIENCES CORPORATION TITLE SYNTHESIS OF PEPTIDE AND NONPEPTIDE OPIOID ANALOGS ABSTRACT: DESCRIPTION: (Adapted from the applicant's abstract) Solid Phase Sciences Corporation (SPSC) proposes to produce a library of heptapeptide analogs and a library of alkylether substituted pyrolidineanalide analogs targeting the delta and k (kappa) opioid receptors. Both compound libraries will consist of 2-5 milligrams each of a total of 192 compounds. SPSC will accomplish this by utilizing it's novel high-loading paramagnetic support and a commercially available solvent delivery robot. Specifically, libraries will be made off of this high-loading paramagnetic support, utilizing sonication to assist in the mixing and running of the reactions. A constant magnetic field will be used to separate the support from the soluble components of the reaction mixture. A liquid handling robot will be used to add reagents and solvents and to remove waste solvents through suction. The goal of the Phase I effort will be to integrate sonication, magnetic separation and automated liquid handling into one automated system to produce a library composed of peptide and non- peptide compounds for opioid receptor screening. $ = TOTAL AWARD AMTS & NOT LIMITED TO PORTION OF PROJECT RELATED TO SUBJECT OF SEARCH SUBPROJECT $ = TOTAL AWARD AMOUNT DIVIDED BY NUMBER OF SUBPROJECTS SOURCE: CRISP FORMAT F FY 97 LAST UPDATE 04-07-98 1QUERY 1536 ID SEARCH 06/01/98 PAGE 247 --PROJECT NUMBER......9 R44 DA11845-02 INVESTIGATOR NAME/ADDRESS FY 97 MICHELSON, STEPHEN A IRG/INTRAMURAL UNIT..ZRG7 CYCLOTEC MED INDUSTRIES INC AWARD AMOUNT......... $527,550 1910 NORTHEAST MIAMI COURT MIAMI BEACH, FL 33132 PERFORMING ORGANIZATION: CYCLOTEC MEDICAL INDUSTRIES, INC. TITLE ELECTRO-THERAPEUTIC PAIN BLOCKING SPLINTS AND BANDAGES NO ABSTRACT ON FILE $ = TOTAL AWARD AMTS & NOT LIMITED TO PORTION OF PROJECT RELATED TO SUBJECT OF SEARCH SUBPROJECT $ = TOTAL AWARD AMOUNT DIVIDED BY NUMBER OF SUBPROJECTS SOURCE: CRISP FORMAT F FY 97 LAST UPDATE 04-07-98 1QUERY 1536 ID SEARCH 06/01/98 PAGE 248 --PROJECT NUMBER......1 R43 DC02911-01A2 INVESTIGATOR NAME/ADDRESS FY 97 JOACHIM, DALE IRG/INTRAMURAL UNIT..ZRG1 SILENT CALL CORPORATION AWARD AMOUNT......... $84,339 2220 SCOTT LAKE ROAD WATERFORD, MI 48328 PERFORMING ORGANIZATION: SILENT CALL CORPORATION TITLE ADAPTIVE ALERTING SYSTEM FOR DEAF PERSONS ABSTRACT: The long-term goal of this project is the development of an adaptable digital-signal-processing-based alerting system for person with hearing disabilities that will be used to make the owner aware of important sounds (e.g.. doorbell, telephone, smoke detector, infant crying) in his/her hone, office car classroom, or other environment. The product must be capable of detecting these sounds in "acoustically hostile" environments such as when a television is operating. The system will be flexible and portable and will be trained by the owner to recognize an array of sounds of the owner's choosing. The critical technological issues to be explored are the development of a robust signal detection system based on artificial neural network leaning algorithms to "teach" the system new sounds (and to extinguish alerts to inappropriate ones), and, ultimately, the design and manufacture of application specific integrated circuitry to implement the algorithms.