SMALL BUSINESS INNOVATION RESEARCH (SBIR): UNIVERSAL MEDIA FOR MAINTENANCE OF MESODERMAL LINEAGE MPS SYSTEMS

Microphysiological systemsMPSdevelopment has advanced as a means to reducerefineand replace animal studiesto improve models of human diseaseUsage of MPS systems for such applications will require standardization of technology componentsTowards this effortNational Center for Advancing Translational SciencesNCATSinvestigators have identified the need for a universal medium for supporting the survival and support of multiple tissues in human induced pluripotent stem celliPSCMPS constructs simultaneouslyLaCella stem cell andculture reagent manufacturerhas commercialized proprietary medium products for forming fatboneand cartilageLaCell and Obatala Sciences propose addressing this need with the objectives of demonstrating that its media products can support survival and tissue formation of human iPSCand that multiple products can be combined systematically to optimize a medium that supports multiple tissuesWe anticipate that an optimal medium can be discovered by altering four key components of tissue formation and this will support at leastcell survival and support one tissue fordays and two tissues simultaneously fordaysSuccessful development of such tools will help to address the translationalethicalsocietaland scientific hurdles pertaining to the development of new human therapies