LIPID POLYMER FILMS-A NOVEL BIOMATERIAL

BIOTECHNOLOGY ASSOCIATES, INC. WILL DEVELOP SURFACE COATINGS COMPOSED OF FILMS OF POLYMERIZED LIPIDS THAT WILL BE NONTHROMBOGENIC AND NONADHESIVE FOR CELLS. THUS THEY MAY PROVIDE USEFUL BIOCOMPATIBLE COATINGS FOR BIOMEDICAL DEVICES. LIPID POLYMER FILMS WILL ALSO BE MODIFIED BY COUPLING OF ADHESION PROTEINS OR PEPTIDES TO PROVIDE SURFACES WITH CONTROLLED CELL ADHESION PROPERTIES IN THE ABSENCE OF SERUM. SUCH SURFACES SHOULD BE USEFUL FOR THE SERUM-FREE GROWTH OF CELLS, ESPECIALLY IN THE CONTEXT OF EXPRESSION AND ISOLATION OF RECOMBINANT DNA PRODUCTS IN MAMMALIAN CELL CULTURE.