SBIR/STTR Research Award
PRODUCTION OF DENQUE 2 ENVELOP PROTEIN IN THE YEAST SACCHAROMYCES CEREVISIAE
Award amount
$571,526Program and phase
SBIR · Phase IIAward year
1991Award details
- Awarding agency
- Department of Defense
- Branch
- Army
- Recipient company
- HAWAII BIOTECH, INC.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- ECJKEEFL4L51
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
THE FOUR SEROTYPES OF DENGUE VIRUSES ARE A LEADING CAUSE OF MORBIDITY THROUGHOUT THE TROPICS AND SUBTROPICS. FOR USE IN DIAGNOSTICS AND IN SUBUNIT VACCINES AGAINST DENGUE, A RELIABLE AND INEXPENSIVE SOURCE OF DENGUE ANTIGENS IS REQUIRED. FOR THESE PURPOSES, EXPRESSION OF RECOMBINANT ANTIGENS IN MICROORGANISMS IS BEST SUITED. WE PROPOSE TO USE THE YEAST SACCHAROMYCES CEREVISIAE TO PRODUCE THE DENGUE 2 VIRUS ENVELOPE GLYCOPROTEIN. THE SEQUENCES ENCODING THE ENVELOP PROTEIN WILL BE PLACED UNDER THE TRANSCRIPTIONAL CONTROL OF BOTH A CONSTITUTIVE AND A REGULATED PROMOTER, WITH AND WITHOUT SECRETION SIGNAL PEPTIDES. RELATIVE AMOUNTS OF ANTIGENIC MATERIAL WILL BE DETERMINED FOR EACH SYSTEM.
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- Chikungunya Recombinant Subunit Vaccine
- Development of a Cross-Protective New World Encephalitic Alphavirus Subunit Vaccine
- Novel TLR-4 Agonists as Vaccine Adjuvants
- RECOMBINANT WEST NILE VIRUS VACCINE ADJUVANTED WITH SLA-LSQ
- Chikungunya Recombinant Subunit Vaccine
Research funding history
103 SBIR/STTR records share this UEI (1983–2024). Reported award amounts total $40,917,853. Reported amounts are not federal obligations.
Phases: Phase I, Phase II, Phase II – Direct to Phase II
Agencies: Department of Health and Human Services, Department of Defense, National Science Foundation, Department of Agriculture