SBIR/STTR Research Award

MOLECULAR MIMICRY AFFINITY CHROMATOGRAPHY

Award identifier 47db37fd29f8fa490197c16f1886f7f61bb23e2b74aec05b727df1d51b41f590Awarding agency Department of Energy

Award amount

$50,000

Program and phase

SBIR · Phase I

Award year

1988

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Award details

Awarding agency
Department of Energy
Branch
Not reported
Recipient company
Terrapin Diagnostics Inc.
Proposal award date
Not reported
Contract end date
Not reported
UEI
Not reported
Solicitation number
Not reported
Topic code
Not reported

Research abstract

SUPERIOR SEPARATION COLUMNS ARE BEING DEVELOPED IN THIS PROJECT TO BE USED WITH HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) SYSTEMS TO DETECT ENVIRONMENTAL TOXINSSUCH AS DDT. THE SEPARATION AND ANALYSIS OF COMPOUNDS BY HPLC SYSTEMS DEPENDS ON THE AMPLIFICATION OF SMALL DIFFERENCES IN THE RELATIVE AFFINITY OF THE COMPOUNDS BETWEEN THE COLUMN MATRIX AND THE SOLVENT. USING A FEW STANDARDIZED COLUMN MATRICES, CURRENT HPLC PROCEDURES REQUIRE ADJUSTMENT OF SOLVENT COMPOSITION TO PROVIDE ADEQUATE SEPARATION OF THE COMPOUNDS. BY CONTRAST, THE CURRENT WORK WILL OPTIMIZE THE COLUMN FOR PREFERENTIAL BINDING OF THE TARGET ANALYTE BY ATTACHING SELECTED MEMBERS OF A NOVEL CLASS OF AFFINITY LIGANDS TO THE COLUMN MATRIX.

Technology keywords

Not reported

Agency intelligence

Department of Energy

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