SYNTHESIS OF QINGHAOSU ANALOGUES AS POTENTIAL ANTIPARASITIC AGENTS

THE SYNTHESIS OF A SERIES OF QINGHAOSU ANALOGUES AS POTENTIAL ANTIPARASITIC AGENTS IS PROPOSED. THESE MATERIALS WILL INCORPORATE THE UNIQUE LACTONE ENDOPEROXIDE FUNCTION ESSENTIAL FOR THE ACTIVITY OF THE PARENT STRUCTURE. THE SYNTHETIC APPROACHES ARE BASED ON WELL-FOUNDED CHEMICAL PRINCIPLES, UTILIZE INEXPENSIVE STARTING MATERIALS, AND SHOULD PROVIDE THE DESIRED COMPOUNDS IN SUFFICIENT QUANTITIES FOR USAMRDC IN VITRO AND IN VIVO BIOLOGICAL EVALUATION PHASE II WILL EXTEND THESE STUDIES TO DEVELOP EVEN MORE ACTIVE ANALOGUES, AS WELL AS TO PRODUCE LARGER QUANTITIES OF PROMISING COMPOUNDS FOR FURTHER TESTING.