SBIR/STTR Research Award
ACCELERATED WOUND HEALING WITH FIBROBLAST GROWTH FACTOR
Award amount
$500,000Program and phase
SBIR · Phase IIAward year
1988Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- California Biotechnology, Inc.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
BASIC AND ACIDIC FIBROBLAST GROWTH FACTORS (FGF) ARE TWO PRIMARY MITOGENS FOR CAPILLARY ENDOTHELIAL CELLS. BOVINE BASIC FGF, ISOLATED FROM PITUITARIES, WILL BE USED IN RAT WOUND HEALING MODELS TO DETERMINE WHETHER THIS FACTOR CAN ACCELERATE THE RATE OF WOUND HEALING THROUGH PROMOTING ANGIOGENESIS. THIS IS THE FIRST STEP TOWARDS DEVELOPING A THERAPY THAT WILL BE USED IN THE TREATMENT OF BURN AND OTHERTRAUMA VICTIMS WHO HAVE POORLY HEALING WOUNDS. TO OBTAIN A SOURCE OF THE HUMAN FGFS, FOR FURTHER ANIMAL TESTS AND FOR EVENTUAL CLINICAL TRIALS, THE DNA SEQUENCES ENCODING BOTH BASIC AND ACIDIC FGF WILL BE CLONED. THIS WILL ALLOW THE FUTURE DEVELOPMENT OF RECOMBINANT DNA EXPRESSION SYSTEMS FORHUMAN PROTEINS.
Technology keywords
Not reported