SBIR/STTR Research Award
Affinity Capture Peptides for Clinical Mass Spectrometric Assays in Plasma
Award amount
$283,799Program and phase
SBIR · Phase IAward year
2014Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- AFFINERGY, LLC
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- YJQ6K1QMS488
- Solicitation number
- PA13-234
- Topic code
- NIGMS
Research abstract
DESCRIPTION (provided by applicant): We will develop the first assay for multiplexed combinations of all 14 Bone Morphogenetic Proteins. Immunoassays are the gold standard for measuring proteins in clinical samples. However these antibody- based tests neither quantitate protein analyte variants, nor multiplex across large numbers of superfamily members. In addition, the availability of polyclonal and monoclonal antibodies is limited. We propose a novel solution to these problems, firstly by modifying a mass spectrometric immunocapture assay to use affinity capture-peptides to enrich clinically relevant protein variants. Secondly by exploitin the efficient and high- throughput production of synthetic peptides from phage display libraries as targeted capture-reagents. For proof-of-concept, we will develop a quantitative prototype assay for multiplexed combinations of all 14 Bone Morphogenetic Protein (BMP) members in human plasma. Phase II will validate multiplexed assays for the whole BMP/Transforming G
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- A novel peptide assay for hepcidin clinical monitoring
- A Rapid Point of Care Test for APOL1 Renal Risk Alleles
- Novel clinical assay to rapidly monitor posaconazole levels in plasma
- Immunoprofiling to develop a novel diagnostic array for cardiac sarcoidosis
- Rapid assay to monitor vancomycin levels at the point of care in hemodialysis patients
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Three-Dimensional Spatio-Temporal Control of Lipid Nanoparticle Manufacturing for Improved Nucleic Acid Delivery
- Paradigm-changing, versatile, scalable and cost-effective technology for monthly injections of peptide drugs
- Project MATCH: Multi-spectral AI/ML powered Burn and Wound Evaluation Technology using a Cost-Effective Handheld Device.
- A versatile platform to isolate cells from three-dimensional samples after spatial and temporal profiling
- Development of an Educational Product for Accelerating Solutions for Commercialization and Entrepreneurial Development (ASCEND) in Western IDeA States
Research funding history
75 SBIR/STTR records share this UEI (2005–2023). Reported award amounts total $59,804,968. Reported amounts are not federal obligations.
Phases: Phase I, Phase II, Phase II – Direct to Phase II
Agencies: Department of Health and Human Services